Expression of a novel PDGF isoform, PDGF-C, in experimental periapical lesions.
作者： Li Wang , Rui Zhang , Bin Peng
DOI: 10.1016/J.JOEN.2008.11.030
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摘要: Abstract The purpose of this study was to examine the expression platelet-derived growth factor C (PDGF-C), which is a new member PDGF family, in experimental periapical lesions. Periapical lesions were induced Sprague-Dawley rats by occlusal pulp exposure mandibular first molars. Animals sacrificed randomly at 0, 7, 14, 21, and 28 days after exposure. Frontal sections prepared for histological analysis enzyme histochemistry. Reverse-transcription polymerase chain reaction immunohistochemistry performed detect PDGF-C expression. From day 0 28, messenger RNA expressed increased until 28. A few PDGF-C–positive cells osteoclasts could be observed on 7. Both ascended number 14. In 21- 28-day samples, increased, whereas fewer observed. Many inflammatory with different morphologies. These findings showed that might also involved pathogenesis
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