Transmucosal Solid Lipid Nanoparticles to Improve Genistein Absorption via Intestinal Lymphatic Transport.
作者： Paolo Giunchedi , Rossana Migheli , Elisabetta Gavini , Grazia Galleri , Giovanna Rassu
DOI: 10.3390/PHARMACEUTICS13020267
关键词:
摘要: Genistein (GEN) is a soy-derived isoflavone that exhibits several biological effects, such as neuroprotective activity and the prevention of types cancer cardiovascular disease. However, due to its poor water solubility extensive first-pass metabolism, oral bioavailability GEN limited. In this work, solid lipid nanoparticles (SLN) were developed preferentially reach intestinal lymphatic vessels, avoiding metabolism GEN. GEN-loaded SLN obtained by hot homogenization process, formulation parameters chosen based on already formulated studies. The characterized, preliminary in vitro chylomicron formation was evaluated. cell uptake selected nanocarriers studied Caco-2 line mucosa. SLN, characterized spherical shape, showed an average diameter (about 280 nm) suitable for uptake, good stability during testing time, high drug loading capacity. Furthermore, mucosa cells found SLN. approximately two-fold increase particle size suggested possible interaction between components chylomicrons like phospholipid; therefore, results may support potential these improve via absorption.
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