Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone
作者： Leire Ruiz-Rubio , María Alonso , Leyre Pérez-Álvarez , Rosa Alonso , Jose Vilas
关键词:
摘要: Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due its valuable physicochemical and biological properties. This work presents a formulation poorly-water soluble drug, hydrocortisone, using interpolymer complexes physical blends poly(2-ethyl-2-oxazoline)s two Carbopols® (Carbopol 974 Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release mucoadhesive properties series tablet obtained by combination different Carbopols with molecular weights have been evaluated vitro.
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