Cell-cell adhesion molecules and their associated proteins in bladder cancer cells and their role in mitogen induced cell-cell dissociation and invasion.

作者: Wen Guo Jiang , Malcolm David Mason , G. Davies

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摘要: Three bladder cell lines (EJ138, RT112/84 and T24/83) were used to examine the expression of E-cadherin, desmoglein, their associated proteins role in cell-cell dissociation invasion using hepatocyte growth factor/scatter factor (HGF/SF). Both immunocytochemistry Western blotting revealed that cells expressed high levels alpha-, beta-, gamma-catenins. However, there was no E-cadherin very low alpha- beta-catenin detected both EJ138 T24/83 cells. In contrast, all three found express desmoplakin c-Met. An vitro assay showed highly invasive, however, have limited invasion. Invasion significantly increased by inclusion either antibody or motogen (HGF/SF) culture medium. This did not appear be case for Using immunoprecipitation, HGF/SF induced tyrosine phosphorylation but desmoplakin. It is concluded plays a stronger than desmosomal cadherin control cancer Activation subsequent dysfunction may key mechanism induction motogen, HGF/SF.

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