Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK

摘要: Ocular neovascularization is a devastating pathology of numerous ocular diseases and major cause blindness. Caveolin-1 (Cav-1) plays important roles in the vascular system. However, little known regarding its function mechanisms neovascularization. Here, using comprehensive model systems cell permeable peptide Cav-1, cavtratin, we show that Cav-1 critical player The genetic deletion exacerbated cavtratin administration inhibited choroidal retinal Importantly, combined anti-VEGF-A more effectively than monotherapy, suggesting existence other pathways by addition to VEGF-A. Indeed, found suppressed multiple components pathological angiogenesis, including inflammation, permeability, PDGF-B endothelial nitric oxide synthase expression (eNOS). Mechanistically, inhibits CNV survival migration microglia macrophages via JNK. Together, our data demonstrate unique advantages antiangiogenic therapy treat neovascular diseases.