Safeguarding patients in clinical trials with high mortality rates.

作者: BRADLEY D. FREEMAN , ROBERT L. DANNER , STEVEN M. BANKS , CHARLES NATANSON

DOI: 10.1164/AJRCCM.164.2.2011028

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参考文章(20)
James Knox, Robert Demling, Douglas Wilmore, Pasha Sarraf, Alfred Santos, Increased survival after major thermal injury: the effect of growth hormone therapy in adults. Journal of Trauma-injury Infection and Critical Care. ,vol. 39, pp. 526- 532 ,(1994) , 10.1097/00005373-199509000-00021
C. E Wright, D. D Rees, S. Moncada, Protective and pathological roles of nitric oxide in endotoxin shock Cardiovascular Research. ,vol. 26, pp. 48- 57 ,(1992) , 10.1093/CVR/26.1.48
Ziad Hussein, Misba Beerahee, Robert Grover, Bernadette Jordan, Roger Jeffs, Jill Donaldson, David Zaccardelli, Gene Colice, Kalpalatha Guntupalli, David Watson, Jean‐Louis Vincent, Glaxo Wellcome International Septic Shock Study Group, Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock Clinical Pharmacology & Therapeutics. ,vol. 65, pp. 1- 9 ,(1999) , 10.1016/S0009-9236(99)70116-5
G.A. Ponting, T.D. Teale, D. Halliday, A.J.W. Sim, POSTOPERATIVE POSITIVE NITROGEN BALANCE WITH INTRAVENOUS HYPONUTRITION AND GROWTH HORMONE The Lancet. ,vol. 331, pp. 438- 440 ,(1988) , 10.1016/S0140-6736(88)91232-9
Robert Grover, David Zaccardelli, Gene Colice, Kalpalatha Guntupalli, David Watson, Jean-Louis Vincent, An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock Critical Care Medicine. ,vol. 27, pp. 913- 922 ,(1999) , 10.1097/00003246-199905000-00025
Robert J. Przybelski, Elaine K. Daily, James C. Kisicki, Cynthia Mattia-Goldberg, Marilyn J. Bounds, Wayne A. Colburn, Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution. Critical Care Medicine. ,vol. 24, pp. 1993- 2000 ,(1996) , 10.1097/00003246-199612000-00011
Robert Grover, Jan Bakker, Angela McLuckie, Jan Andersson, Jean-Roger LeGall, THE NITRIC OXIDE SYNTHASE INHIBITOR 546C88 PROMOTES THE RESOLUTION OF SHOCK IN PATIENTS WITH SEVERE SEPSIS Critical Care Medicine. ,vol. 26, ,(1998) , 10.1097/00003246-199801001-00025