Analysis of miRNA Targets in Correlation to Neurodevelopment and Diagnosis of Autism Spectrum Disorder (ASD)
作者： Emir Šehović , Lemana Spahić , Ajla Kulaglić , Lejla Smajlović-Skenderagić , Aida Hajdarpašić-Saračević
DOI: 10.1007/978-3-030-17971-7_56
关键词:
摘要: Autism Spectrum Disorder (ASD) is a broad spectrum of disorders which manifests itself through number different phenotypes including those affecting communication and behavior. Our aim was to investigate small non coding RNA molecules, miRNAs, their effect on target genes involved in neurodevelopment ASD. In addition, we performed our study by investigating selected miRNAs as potential biomarkers for diagnosing children with MiRNAs this are found saliva samples; therefore, sampling non-invasive very attractive diagnostic tool Children diagnosed at an early stage life would have the most benefit from intervention. We identified 7 suspected be ASD silico analysis. negative regulatory interactions between differentially expressed putative targets The seven all connected neurodevelopmental functions processes. Malfunction some or these connection and/or other disorders. following were best candidate studied: MAPK10, KCNMA1, DST, ZBTB20, GAS7, NTRK2 SCN2A.
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