Progenitor Cells of the Adult Human Subcortical White Matter
作者： Neeta S. Roy , Martha S. Windrem , Steven A. Goldman
DOI: 10.1016/B978-012439510-7/50063-2
关键词:
摘要: Publisher Summary Oligodendrocyte progenitor cells (OPCs) seem to be extraordinarily widespread in the adult mammalian brain. The principal class of OPCs rodents is a bipotential astrocyte-oligodendrocyte cell designated O-2A progenitor, by virtue its generation vitro oligodendrocytes and type 2 astrocytes, latter comprising traditionally recognized fibrous astrocytes white matter. may specifically targeted isolated from This chapter outlines basic strategies for isolating matter, using either fluorescence-activated sorting (FACS) or higher-yield, less-specific alternative immunomagnetic isolation (MACS). Adult-human white-matter (WMPCs) give rise multipotential neurospheres. Nonetheless, very existence progenitors scattered throughout parenchyma forces one reconsider understanding both nature incidence neural stem brain, challenges conception supposed rarity cells. In doing so, they point an abundant source that used as target pharmacological induction appropriate therapeutic engraftment diseased
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