Assessment of blending performance of pharmaceutical powder mixtures in a continuous mixer using Discrete Element Method (DEM)

作者: Andrew Bayly , Mohammadreza Alizadeh Behjani , Yousef Ghaffari Motlagh , Andrew E Bayly , Ali Hassanpour

DOI: 10.1016/J.POWTEC.2019.10.102

关键词:

摘要: This study proposes a new sample-independent mixing index, termed the Coefficient of Blending Performance (CBP), for monitoring the formation of undesired API (Active …

参考文章(58)
Umang V Shah, Zihua Wang, Dolapo Olusanmi, Ajit S Narang, Munir A Hussain, Michael J Tobyn, Jerry YY Heng, None, Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders International Journal of Pharmaceutics. ,vol. 495, pp. 234- 240 ,(2015) , 10.1016/J.IJPHARM.2015.08.061
Maxx Capece, Raimundo Ho, John Strong, Ping Gao, Prediction of powder flow performance using a multi-component granular Bond number Powder Technology. ,vol. 286, pp. 561- 571 ,(2015) , 10.1016/J.POWTEC.2015.08.031
Theresa Beyer, Graeme M. Day, Sarah L. Price, The prediction, morphology, and mechanical properties of the polymorphs of paracetamol. Journal of the American Chemical Society. ,vol. 123, pp. 5086- 5094 ,(2001) , 10.1021/JA0102787
M Lemieux, François Bertrand, Jamal Chaouki, P Gosselin, None, Comparative study of the mixing of free-flowing particles in a V-blender and a bin-blender Chemical Engineering Science. ,vol. 62, pp. 1783- 1802 ,(2007) , 10.1016/J.CES.2006.12.012
G Baumann, I. M Jánosi, D. E Wolf, Particle Trajectories and Segregation in a Two-Dimensional Rotating Drum. EPL. ,vol. 27, pp. 203- 208 ,(1994) , 10.1209/0295-5075/27/3/006
Ali Hassanpour, Hongsing Tan, Andrew Bayly, Prasad Gopalkrishnan, Boonho Ng, Mojtaba Ghadiri, Analysis of particle motion in a paddle mixer using Discrete Element Method (DEM) Powder Technology. ,vol. 206, pp. 189- 194 ,(2011) , 10.1016/J.POWTEC.2010.07.025
Troy Shinbrot, Marco Zeggio, Fernando J Muzzio, Computational approaches to granular segregation in tumbling blenders Powder Technology. ,vol. 116, pp. 224- 231 ,(2001) , 10.1016/S0032-5910(00)00394-6
Basel Alchikh-Sulaiman, Farhad Ein-Mozaffari, Ali Lohi, Evaluation of poly-disperse solid particles mixing in a slant cone mixer using discrete element method Chemical Engineering Research & Design. ,vol. 96, pp. 196- 213 ,(2015) , 10.1016/J.CHERD.2015.02.020
L.T. Fan, R.H. Wang, On mixing indices Powder Technology. ,vol. 11, pp. 27- 32 ,(1975) , 10.1016/0032-5910(75)80018-0
Stefan Radl, Eva Kalvoda, Benjamin J. Glasser, Johannes G. Khinast, Mixing characteristics of wet granular matter in a bladed mixer Powder Technology. ,vol. 200, pp. 171- 189 ,(2010) , 10.1016/J.POWTEC.2010.02.022