DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population.
作者： Sandra Costa , Daniela Pinto , Deolinda Pereira , Helena Rodrigues , Jorge Cameselle-Teijeiro
DOI: 10.1007/S10549-006-9364-Z
关键词:
摘要: The purpose of this study was to evaluate the role polymorphisms in DNA repair genes as genetic indicators susceptibility familial and sporadic breast cancer. We analysed samples from 285 cancer patients 442 control subjects, for XRCC1Arg399Gln, XPDLys751Gln, RAD51G135C XRCC3Thr241Met using PCR-RFLP. observed that women carriers XRCC1399Gln genotypes without family history have a protective effect concerning disease (OR = 0.54 95% CI 0.35–0.84; p 0.006). Furthermore, we found XRCC3241Met FH an increased 2.21 1.42–3.44; < 0.001). Additionally, verified risk with carrying RAD51135C 2.17 1.19–3.98; 0.012). Our results suggest XRCC1Arg399Gln important biomarkers susceptibility, well as, polymorphism real modifier cases.
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