Metabolic Control in 131 Juvenile-onset Diabetic Patients as Measured by HbA1c: Relation to Age, Duration, C-Peptide, Insulin Dose, and One or Two Insulin Injections

摘要: Glycosylated hemoglobin A (HbA 1c ), considered to reflect long-term metabolic control of diabetes, was analyzed in 131 patients, aged 2 5/12–19 6/12 yr, with juvenile-onset diabetes. Using stepwise multiple regression HbA , fasting blood glucose and plasma 3-hydroxybutyrate were as dependent variables versus independent such age the duration disease, level immunoreactive C-peptide (IRCP), insulin dose, number injections (one or two) per day. inversely related only IRCP concentration. low but significant, positive correlation found between Stepwise addition other did not further increase fraction explained variance. also correlated a subjective rating score performed by treating physician. Fasting significantly any variables. showed an inverse patient. The present study that diabetic endogenous secretion reflected factor best . After cessation secretion, there is progressive deterioration rather than one two day may be needed reach optimal patients.