Focus on the intermediate state: immature mRNA of cytochromes P450—methods and insights

摘要: The scattered and limited data on hnRNAs (pre-mRNAs) of cytochromes P450 (CYP) are compiled discussed for the first time. methods determination quantification compared. In most cases, CYP hnRNA levels were determined as a parameter transcriptional activity. It is known, however, that some CYPs, in particular CYP2E1, addition specifically extensively regulated by post-transcriptional processes. Obviously, these processes also influence processing so their cannot be considered mere result transcription. underlying mechanisms mRNA regulation not well understood. our aim therefore to bring together available discuss them light recent advances knowledge concerning pre-mRNA interactions between RNA low molecular weight interfering RNAs. By doing this, we hope drive research direction which appears promising providing long-awaited answers with respect regulation.