Inflammatory Pathology in Alzheimer’s Disease

摘要: A large body of evidence suggests that there is an inflammatory component to Alzheimer’s disease (AD) pathogenesis. The reactive microglial cells neuritic plaques are characterized by the presence a variety markers, including HLA-DR, HLA-DP, HLA-DQ, β-2 integrins and Fc receptors (reviewed Rogers et al., 1992a). Also evident within As associated proteins (Selkoe, 1991), many which related processes. Some most studied α 1-antichymotrypsin (ACT) (Abraham 1988), complement (McGeer McGeer, 1992; McGeer Rogers, 1992), serum amyloid P (SAP) (Coria 1988) heparin sulfate proteoglycans (HSPG) (Snow 1988). Furthermore, altered levels cytokine interleukin 1 (IL-1) IL-6 have been demonstrated in AD Wood 1993).