Serum Creatinine Phosphokinase In Acute Myocardial Infarction

摘要: CREATINE phosphokinase (CPK) is an enzyme abundantly present in skeletal and cardiac muscle cells. It catalyzes the phosphorylation of creatine, a reversible reaction requiring adenosine triphosphate (ATP): In 1959 Ebashi et al first utilized measurement this as diagnostic aid. 1 They determined serum creatine (SCPK) patients with muscular disorders found abnormal elevations large percentage progressive dystrophy Duchenne type. Other investigators have since confirmed these findings 2-4 addition enlarged possibilities by finding abnormally high SCPK values other affecting tissue, such dermatomyositis 3,4 hypothyroidism, 5 following surgery, 6 during acute myocardial infarction. 7-10 Since CPK so heavily concentrated muscle, opposed to tissues, 11 it possesses potentially degree specificity, contradistinction ubiquitous transaminases dehydrogenases. Therefore, surprising that