Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers

作者: D. Carbajal , M.L. Arruzazabala , S. Valdés , R. Más

DOI: 10.1016/S0952-3278(98)90130-2

关键词:

摘要: … In addition, antiplatelet effects of policosanol have been shown in experimental … of policosanol on platelet aggregation and thromboxane B 2 and prostacyclin (6 keto PGFI~,) production …

参考文章(18)
R. Mas, V. Molina, S. Valdes, C. Aleman, D. Carbajal, M. L. Arruzazabala, L. Fernandez, Effect of policosanol on platelet aggregation in healthy volunteers. International Journal of Clinical Pharmacology Research. ,vol. 16, pp. 67- 72 ,(1996)
Rosa Mas, Vivian Molina, Suria Valdes, Maria de Lourdes Arruzazabala, Abilio Laguna, Daysy Carbajal, Cholesterol-lowering effects of policosanol in rabbits. Biological Research. ,vol. 27, pp. 205- 208 ,(1994)
P. Pons, R. Más, J. Illnait, L. Fernández, M. Rodriguez, C. Robaina, J.C. Fernández, Efficacy and safety of policosanol in patients with primary hypercholesterolemia Current Therapeutic Research-clinical and Experimental. ,vol. 52, pp. 507- 513 ,(1992) , 10.1016/S0011-393X(05)80456-4
M.L. Arruzazabala, V. Molina, D. Carbajal, S Valdés, R. Más, Effect of policosanol on cerebral ischemia in Mongolian gerbils: Role of prostacyclin and thromboxane A2 Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 49, pp. 695- 697 ,(1993) , 10.1016/0952-3278(93)90080-G
G.J. BLACKWELL, W.G. DUNCOMBE, R.J. FLOWER, M.F. PARSONS, J.R. VANE, The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. British Journal of Pharmacology. ,vol. 59, pp. 353- 366 ,(1977) , 10.1111/J.1476-5381.1977.TB07500.X
M. Hamberg, J. Svensson, T. Wakabayashi, B. Samuelsson, Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 345- 349 ,(1974) , 10.1073/PNAS.71.2.345
D. Carbajal, M.L. Arruzazabala, R. Más, V. Molina, S. Valdés, Effect of policosanol on experimental thrombosis models Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 50, pp. 249- 251 ,(1994) , 10.1016/0952-3278(94)90162-7
O. Torres, A. J. Agramonte, J. Illnait, R. M. Ferreiro, L. Fernandez, J. C. Fernandez, Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care. ,vol. 18, pp. 393- 397 ,(1995) , 10.2337/DIACARE.18.3.393