The Rac GTPase in cancer: from old concepts to new paradigms
作者： Marcelo G Kazanietz , Maria J Caloca , None
DOI: 10.1158/0008-5472.CAN-17-1456
关键词:
摘要: Rho family GTPases are critical regulators of cellular functions that play important roles in cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …
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sci-hub.se 参考文章(64)
Inuk Zandvakili, Ashley Kuenzi Davis, Guodong Hu, Yi Zheng, Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice PLOS ONE. ,vol. 10, pp. e0127923- ,(2015) , 10.1371/JOURNAL.PONE.0127923
V Justilien, A P Fields, Ect2 links the PKCι–Par6α complex to Rac1 activation and cellular transformation Oncogene. ,vol. 28, pp. 3597- 3607 ,(2009) , 10.1038/ONC.2009.217
Lloye M Dillon, Todd W Miller, The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer. Molecular and Cellular Oncology. ,vol. 2, ,(2015) , 10.1080/23723556.2014.996016
Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, Andrew E. Aplin, RAC1 P29S regulates PD-L1 expression in melanoma Pigment Cell & Melanoma Research. ,vol. 28, pp. 590- 598 ,(2015) , 10.1111/PCMR.12392
Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom, P-Rex1 is required for efficient melanoblast migration and melanoma metastasis Nature Communications. ,vol. 2, pp. 555- 555 ,(2011) , 10.1038/NCOMMS1560
Verline Justilien, Lee Jameison, Channing J. Der, Kent L. Rossman, Alan P. Fields, Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation Journal of Biological Chemistry. ,vol. 286, pp. 8149- 8157 ,(2011) , 10.1074/JBC.M110.196113
Ian R. Watson, Liren Li, Peter K. Cabeceiras, Mozhdeh Mahdavi, Tony Gutschner, Giannicola Genovese, Guocan Wang, Zhuangna Fang, James M. Tepper, Katherine Stemke-Hale, Kenneth Y. Tsai, Michael A. Davies, Gordon B. Mills, Lynda Chin, The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF Cancer Research. ,vol. 74, pp. 4845- 4852 ,(2014) , 10.1158/0008-5472.CAN-14-1232-T
A Lahoz, A Hall, A tumor suppressor role for srGAP3 in mammary epithelial cells Oncogene. ,vol. 32, pp. 4854- 4860 ,(2013) , 10.1038/ONC.2012.489
S Castillo-Lluva, C-T Tan, M Daugaard, P H B Sorensen, A Malliri, The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. Oncogene. ,vol. 32, pp. 1735- 1742 ,(2013) , 10.1038/ONC.2012.189
Alan Hall, Anne J. Ridley, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. ,vol. 70, pp. 389- 399 ,(1992) , 10.1016/0092-8674(92)90163-7