RAC1 P29S regulates PD-L1 expression in melanoma

摘要: Whole exome sequencing of cutaneous melanoma has led to the detection P29 mutations in RAC1 5-9% samples, but role biology remains unclear. Using reverse phase protein array analysis examine changes protein/phospho-protein expression, we identified cyclin B1, PD-L1, Ets-1, and Syk as being selectively upregulated with P29S expression downregulated depletion. patient samples TCGA, found PD-L1 be significantly increased patients compared WT well other mutants. The finding that is suggests oncogenic may promote suppression antitumor immune response. This a new insight into biological function potential clinical implications candidate biomarker for benefit from treatment anti-PD1 or anti-PD-L1 antibodies.