Zinc-naproxen complex: synthesis, physicochemical and biological evaluation.
作者： Jyoti Sharma , Anil K Singla , S Dhawan
DOI: 10.1016/S0378-5173(03)00251-5
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摘要: Abstract Aspirin has a propensity to cause ulcers and Zn2+ is known possess anti-ulcer as well anti-inflammatory activity. The zinc complex of aspirin was therefore synthesised its structure determined by IR, 1H-NMR, 13C-NMR, UV, DSC, atomic absorption spectroscopy elemental analysis. physicochemical properties the such pH-solubility profile at 25°C partition coefficient were compared with that aspirin. Anti-inflammatory studies (using carrageenan-induced hind paw edema method) showed 2.64-times more potent than 1.73-times physical mixture sulphate. ANOVA followed Duncan's new multiple range test indicated significant difference (p
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