Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
作者： Cynthia J. Burrows , Steven E. Rokita , Xiaoying Chen
DOI:
关键词:
摘要: A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The acid contacted with polyaza metal complex in the presence of an oxidizing agent so that modified at or near Also are kit carrying out and method treating neoplastic growth by administering to subject having growth, effective amount which capable DNA.
google.com.jm 参考文章(33)
M. B. Fleisher, H.-Y. Mei, J. K. Barton, Metal Complexes Which Target DNA Sites: Coupling Recognition to Reactivity Springer Berlin Heidelberg. pp. 65- 84 ,(1988) , 10.1007/978-3-642-83384-7_4
Lidia Hernandez, Kazimierz S. Kasprzak, Enhancement of Hydroxylation and Deglycosylation of 2′-Deoxyguanosine by Carcinogenic Nickel Compounds Cancer Research. ,vol. 49, pp. 5964- 5968 ,(1989)
Jacqueline K. Barton, Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents ,(1986)
David P. Mack, Peter B. Dervan, Nickel-mediated sequence-specific oxidative cleavage of DNA by a designed metalloprotein Journal of the American Chemical Society. ,vol. 112, pp. 4604- 4606 ,(1990) , 10.1021/JA00167A102
J. Barton, Metals and DNA: molecular left-handed complements Science. ,vol. 233, pp. 727- 734 ,(1986) , 10.1126/SCIENCE.3016894
G. B. Dreyer, P. B. Dervan, Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 968- 972 ,(1985) , 10.1073/PNAS.82.4.968
Reuel B. Van Atta, Jean Bernadou, Bernard Meunier, Sidney M. Hecht, On the chemical nature of DNA and RNA modification by a hemin model system Biochemistry. ,vol. 29, pp. 4783- 4789 ,(1990) , 10.1021/BI00472A006
Daryle H. Busch, Distinctive coordination chemistry and biological significance of complexes with macrocyclic ligands Accounts of Chemical Research. ,vol. 10, pp. 392- 400 ,(1978) , 10.1021/AR50130A005
Heungsik Yoon, Thomas R. Wagler, Kenneth J. O'Connor, Cynthia J. Burrows, High turnover rates in pH-dependent alkene epoxidation using NaOCl and square-planar nickel(II) catalysts Journal of the American Chemical Society. ,vol. 112, pp. 4568- 4570 ,(1990) , 10.1021/JA00167A078
A. M. Maxam, W. Gilbert, A new method for sequencing DNA Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 560- 564 ,(1977) , 10.1073/PNAS.74.2.560