Selection of aptamers based on geometry

作者: Jason Andrew Appleton West , Brent Coleman Satterfield

DOI:

关键词:

摘要: Disclosed are methods for performing aptamer preselection based on unique geometry and the content of stems or loops aptamer, which capable providing suitable binders also permit selection aptamers performed essentially entirely a chip other device. Also disclosed kits selection.

参考文章(210)
Pavel I. Kitov, David R. Bundle, On the Nature of the Multivalency Effect: A Thermodynamic Model Journal of the American Chemical Society. ,vol. 125, pp. 16271- 16284 ,(2003) , 10.1021/JA038223N
R. O. Dempcy, K. A. Browne, T. C. Bruice, Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 6097- 6101 ,(1995) , 10.1073/PNAS.92.13.6097
Sanjay Tyagi, Fred Russell Kramer, Molecular Beacons: Probes that Fluoresce upon Hybridization Nature Biotechnology. ,vol. 14, pp. 303- 308 ,(1996) , 10.1038/NBT0396-303
Alan S. Perelson, Byron Goldstein, Sol Rocklin, Optimal strategies in immunology III. The IgM-IgG switch Journal of Mathematical Biology. ,vol. 10, pp. 209- 256 ,(1980) , 10.1007/BF00276984
Dmitriy A Dmitriev, Yulia S Massino, Olga L Segal, Maria B Smirnova, Elena V Pavlova, Konstantin G Gurevich, Oksana V Gnedenko, Yuriy D Ivanov, Galina I Kolyaskina, Alexander I Archakov, Alexander P Osipov, Alexander D Dmitriev, Alexey M Egorov, Analysis of the binding of bispecific monoclonal antibodies with immobilized antigens (human IgG and horseradish peroxidase) using a resonant mirror biosensor Journal of Immunological Methods. ,vol. 261, pp. 103- 118 ,(2002) , 10.1016/S0022-1759(01)00558-0
Angela Relógio, Christian Schwager, Alexandra Richter, Wilhelm Ansorge, Juan Valcárcel, Optimization of oligonucleotide-based DNA microarrays. Nucleic Acids Research. ,vol. 30, ,(2002) , 10.1093/NAR/30.11.E51
Jayne A. Matthews, Larry J. Kricka, Analytical strategies for the use of DNA probes Analytical Biochemistry. ,vol. 169, pp. 1- 25 ,(1988) , 10.1016/0003-2697(88)90251-5
Shaun D. Mendonsa, Michael T. Bowser, In vitro selection of aptamers with affinity for neuropeptide Y using capillary electrophoresis. Journal of the American Chemical Society. ,vol. 127, pp. 9382- 9383 ,(2005) , 10.1021/JA052406N
Akhilesh Ramachandran, James Flinchbaugh, Patricia Ayoubi, Glenn A. Olah, Jerry R. Malayer, Target discrimination by surface-immobilized molecular beacons designed to detect Francisella tularensis. Biosensors and Bioelectronics. ,vol. 19, pp. 727- 736 ,(2004) , 10.1016/J.BIOS.2003.08.004
A. Borst, A. T. A. Box, A. C. Fluit, False-positive results and contamination in nucleic acid amplification assays: Suggestions for a prevent and destroy strategy European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 23, pp. 289- 299 ,(2004) , 10.1007/S10096-004-1100-1