Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.

摘要: Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed microtubule inhibitors. Checkpoint failure premature exit may explain why defective for hZw10 hRod divide with lagging chromosomes. As Zw10 Rod not conserved yeast, our data, combined an accompanying study Drosophila Rod, indicate metazoans require elaborate spindle checkpoint monitor complex kinetochore functions.