Minimal Hepatic Encephalopathy: Effect of H. pylori infection and small intestinal bacterial overgrowth treatment on clinical outcomes

摘要: The effect Helicobacter pylori (Hp) infection and small intestinal bacterial over growth (SIBO) in minimal hepatic encephalopathy (MHE) is not well understood. aim of the study was to determine eradication Hp SIBO treatment on MHE patients with cirrhosis. Patients cirrhosis were enrolled determined by psychometric tests critical flicker frequency analysis. assessed urea breath Hydrogen respectively healthy volunteers. given appropriate treatment. At six weeks follow-up, presence infection, status reassessed. Ninety equal number controls included. 55 (61.1%) cirrhotic group diagnosed have underlying MHE. Among group, present 28 (50.9%) vs. 15 without (42.8%) (p = 0.45). Similarly, 17 (30.9%) 11 (31.4%) (p = 0.95) respectively. In comparison controls, more frequently harboring (47.7% 17.7% (p < 0.001) 31.1% 4.4% On all showed evidence infection. Treatment significantly improved state cirrhotics, however did improve significantly. Additionally, low Model for End-Stage Liver Disease (MELD) score belonging Child class B had better improvement A large either active or MHE, compared controls. cirrhosis, whereas affect outcome these patients.