Effect of Heat Denaturation of Collagen Matrix on Bone Strength

摘要: Bone is often regarded as a composite material consisting of hydroxyapatite (HAp-like) mineral particles, organic matrix (mostly Type I collagen) in microscopic scale. The mechanical properties bone at macroscopic scale depend on the structural organization and constituents It has been considered that density predictor its strength from perspective, but denaturation would also lead to significant loss strength. In this study, heat-treated was examined collagen denatured model, then four-point bending tests impact were conducted assess role for bone. Cortical specimens obtained mid- diaphyses bovine femurs heat treated an oven 2 hours 100, 150, 180 200;C, respectively. stored saline until experiments. elastic modulus caused by measured using testing machine. performed up fracture deflection rate 0.5 mm/min, with inner outer span 10 24 mm Toughness evaluated measuring energy self-made tester. As results tests, heated over 150;C failed low strain region, suggesting brittle behavior. slightly reduced heating temperature, whereas significantly decreased, especially 150;C. test shows heat-induced great influence toughness These suggest not only collagenmolecules cross-links play important