Energy transfer cassettes in silica nanoparticles target intracellular organelles

摘要: Lipophilic energy transfer cassettes like 1 and 2 are more conveniently synthesized than the corresponding hydrophilic compounds, but they not easily used in aqueous media. To overcome latter issue, were separately encapsulated silica nanoparticles (ca. 22 nm) which freely disperse Photophysical properties of dyes 1–SiO2 2–SiO2 recorded. The permeated into Clone 9 rat liver cells targeted only ER. A high degree was observed this organelle such that most light fluoresced from acceptor part, i.e. particles appeared red. Silica also mitochondria endocytic vesicles (lysosomes or endosomes). In these organelles red red/green respectively. Thus cargo inside influences where localize cells, environment changes fluorescent dyes. Neither findings anticipated given type generally considered to be non-porous.