Localization of lymphocyte subpopulations in peripheral lymphoid organs: Directed lymphocyte migration and segregation into specific microenvironments

摘要: The distribution of lymphocytes in the peripheral lymphoid organs is controlled by recirculatory and microenvironmental factors. Specific interactions between recirculating high endothelial venules various determine presence proportions sets subsets those organs. Separate determinants on node Peyer's patch endothelium along with complementary lymphocyte receptors mediate this organ specificity. B T cells also exhibit nonrandom organization within tissues; after entry via they segregate into their respective domains, which appear to be determined distinct types nonlymphoid stromal cells. Antigenic stimulation results changes phenotype as well microenvironment. response most complex antigens formation germinal centers (GC) composed primarily proliferating cells; few therein supportive GC a site B-T interaction. GCs suggest role for immunoglobulin class switching determination subsequent homing