Assessment of two novel ventilatory surrogates for use in the delivery of gated/tracked radiotherapy for non-small cell lung cancer.

摘要: Abstract Background In selected patients with NSCLC the therapeutic index of radical radiotherapy can be improved gating/tracking technology. Both techniques require real-time information on target location. This is often derived from a surrogate ventilatory signal. We assessed correlation two novel signals spirometer-derived The were obtained using VisionRT stereoscopic camera system. VisionRT-Tracked-Point (VRT-TP) signal was tracking point located midway between umbilicus and xiphisternum. VisionRT-Surface-Derived-Volume (VRT-SDV) 3D body surface imaging torso. have potential advantages over current signals. Methods Eleven subjects recruited. Each positioned as for treatment, then instructed to breathe in five different modes: normal, abdominal, thoracic, deep shallow breathing. Synchronous recorded later analysis. analysed across all modes breathing, phase shifts. VRT-SDV also its ability determine mode Results respiratory showed good ( r >0.80) spirometry 9 11 subjects. For better than VRT-TP Only one subject displayed shift VisionRT-derived spirometry. could differentiate Unlike signal, neither drift. Conclusion applications ventilatory-gated tracked radiotherapy. They used sorting 4DCT images, drive single- multiple-parameter motion models.