Expression profiles of microRNAs and their target genes in papillary thyroid carcinoma.

摘要: The incidence of thyroid cancer has recently experienced a rapid increase in China, and papillary carcinoma (PTC) accounts for nearly 80% human cancers. In the present study, differential expression microRNAs (miRNAs) their target genes were identified order to analyze potential roles miRNAs as biomarkers carcinogenesis. One hundred twenty-six PTC samples collected from patients at China-Japan Union Hospital, gene/miRNA profiles examined with Illumina BeadChips verified by real‑time RT-PCR. Gene Ontology (GO) categories determined, pathway analysis was carried out using KEGG. miRNA predicted implementing three computational programs: TargetScanS, DIANA-microT PicTar. Two forty-eight 3,631 found be significantly deregulated (gene, P<0.05; miRNA, P<0.01) tissues when compared matching normal tissues. hsa-miR-206 (target gene, MET), hsa-miR-299-3p ITGAV), hsa-miR-101 ITGA3), hsa-miR-103 ITGA2), hsa-miR‑222 genes, KIT AXIN2), hsa-miR-15a AXIN2 FOXO1) hsa-mir-221 KIT) identified. Together functions we further elucidated role carcinogenesis suggest use early diagnosis. Our findings provide basis future studies field miRNA-based therapy.