Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome.

摘要: INTRODUCTION Women with Turner's syndrome (TS) have a threefold increase in mortality, primarily as result of their cardiovascular complications. Recently, the risk fatal aortic dissection has come to light major cause mortality women TS. The aim this study was assess prevalence root dilatation group TS and investigate factors contributing its development. METHODS Thirty-eight attending dedicated adult Turner clinic were examined clinically by M-mode two-dimensional echocardiography on at least one occasion. Aortic defined an diameter greater than 95th centile for body surface area. Fasting serum lipid concentrations measured all women. Additionally, 18 subjects underwent noninvasive assessment central arterial stiffness using applanation tonometry. RESULTS Fifty percent hypertensive similar number had abnormal echocardiogram. A bicuspid valve present 33% subjects, 16 (42%) ascending dilatation. This associated four hypertension 11. Two isolated significantly systolic blood pressure (r = 0.5, P 0.003) left ventricular thickness 0-5, 0.02). There no association lipids or compliance. CONCLUSIONS Structural cardiac abnormalities are up 50% syndrome. is significant closely dependent pressure. does not appear be related atherosclerosis more likely due mesenchymal defect. Regular surveillance essential should treated aggressively when order minimize potentially dissection.