[Controlled study of the administration of CDP-choline to preterm newborn infants with respiratory distress syndrome].

摘要: A randomized prospective double-blind trial of CDP-Choline administration to a group 24 preterm newborn infants with respiratory distress syndrome is reported. CDP-choline was administered by the intravenous route (100 mg/kg/day) for seven days, or until less than 30% supplemental oxygen needed. By fifth day life, patients who received required longer period time, and had lower lecithin/sphingomyelin ratio palmitic acid percentage those in control group. At dose given, did not induce postnatal pulmonary maturity. In fact, it may even decrease lecithin synthesis.