Calcium Channelopathy Mutants and Their Role in Ocular Motor Research

摘要: : Thanks to technical advances in eye movement recording, the mouse is destined become increasingly important ocular motor research. An advantage of this species wide range existing mutant strains and techniques generate new mutations affecting specific cell types. Mutations ion channels may be used modulate intrinsic properties neurons, approach insight into degree which neuronal computations depend upon those as opposed circuits neurons. Dendritic calcium currents carried by P-type voltage-activated have been widely postulated perform computational functions cerebellar Purkinje cells. channel lead human diseases, several ataxic mice are now known harbor channel. Murine P-channel mutants such rocker ataxic, but normal or near-normal numbers cells thus offer opportunity study effects biophysical perturbations outright destruction inactivation. Initial studies reveal an array abnormalities, including static hyperdeviation eyes attenuation vestibulo-ocular reflex gains at high stimulus frequencies. The pattern gain phase abnormalities entirely different lurcher, degenerate. progress with animal age, underscoring importance careful attention age when performing short-lived species.