Ion channels in viruses

摘要: This chapter deals with the influenza pandemic that has killed more people than did first and second World Wars combined. Three types of viruses (A, B C) can be distinguished by their nucleoproteins. They vary in extent to which surface proteins mutate, highest mutation rates being found for type A virus. All must enter a host cell proliferate as they lack necessary biochemical machinery manufacture themselves. Once inside cell, multiply rapidly new virus particles are then released budding from membrane. The is surrounded lipid membrane, known “the viral envelope,” derived plasma membrane cell. Embedded within this envelope three integral encoded RNA. These haemaggluttinin, neuraminidase M2 protein. Haemaggluttinin involved attachment subsequent internalization, while protein proton channel plays key role replication. There only 4–16 channels mature particle. genetic information contained consists five separate strands single-stranded entwined together spiral structure associated nucleocapsid RNA transcriptase. it influences replication described. Under drug therapy antiviral drugs amantadine rimantidine highly specific ineffective against or C viruses. block inhibiting external side appears Different proteins, however, play similar life cycle other