Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial

摘要: We assessed the cross-sectional relationship of age, menopausal years, body mass, previous estrogen use, and ethnic background to bone mineral status in a sample 875 healthy postmenopausal women at time they were recruited from community participate multicenter clinical trial. The 1-10 years postmenopause, 45-64 had not received replacement therapy within 3 months enrollment. Of participants, 89% white, 69% spontaneous menopause, 53% history therapy. Bone density (BMD) lumbar spine (L2-4) proximal femur was measured by dual-energy x-ray absorptiometry. Results consistent with significant negative linear regression BMD on age or menopause. Body mass index (BMI) correlated significantly all sites (L 2-4 r = 0.28; femoral neck 0.34, p < 0.0001). adjusted for BMI higher both who taken versus those (L2-4 0.976 +/- 0.009 0.932 0.01; 0.740 0.006 0.708 0.008, 0.05). Adjusted also increased duration ERT. Parity negatively associated L2-4 (p 0.03) but did correlate neck. Black highest BMD, Hispanic even when results BMI. When data corrected differences size, these interethnic no longer significant. conclude that is positively this may confer degree skeletal protection heavier women. Exposure 5 exogenous age- BMI-adjusted BMD.