Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia.

摘要: Antibody responses are often considered to play only a limited role in controlling viremia during chronic infections with human or simian immunodeficiency virus (SIV). We investigated this by determining the effect of passively infused antibody on plasma infected rhesus macaques. The emphasis study was understand mechanism(s) underlying any observed effects. serum immunoglobulins (SIVIG) purified from SIV(mac)251-infected macaques into other rapid progressor recipients had high viral loads but negligible titers antibodies SIV. Thus, we could significantly increase exogenous SIVIG. Despite restoring anti-SIV levels typical normal disease course, SIVIG modest SIV RNA and cell-associated load; maximum, transient, reduction threefold. decrease commenced within 1-2 h infusion, nadir at 12 h, then rebound occurred. A two- threefold drop simultaneous RNA. kinetics changes inconsistent neutralization new cycles infection. More likely, perhaps unexpectedly, is that killed SIV-infected cells, via an effector mechanism such as antibody-dependent cellular cytotoxicity.