Identification of Dibenzo[a,l]pyrene-DNA Adducts Formed in Cells in Culture and in Mouse Skin
作者： Sherry L. Ralston , Hudson H. S. Lau , Albrecht Seidel , Andreas Luch , Karl L. Platt
DOI: 10.1080/10406639408031185
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摘要: Abstract The DNA adducts formed from the potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) in cultures of Sencar mouse embryo cells and a keratinocyte cell line epidermis vivo were analyzed by 35S−phosphorothioate postlabeling, immobilized boronate chromatography reverse-phase HPLC. results demonstrate that major result activation DB[a,l]P to DB[a,l]P-11,12-diol-13,14-epoxide. Adducts both syn− anti−isomers this diol epoxide are culture, but only anti−isomer detected.
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