Recent progress in natural products as DPP-4 inhibitors.
作者： Yuanyuan Gao , Yong Zhang , Jianming Zhu , Bo Li , Zhao Li
DOI: 10.4155/FMC.15.49
关键词:
摘要: Diabetes mellitus is a chronic disease affecting patients' daily life and increasing risk of other complication. Dipeptidyl peptidase-4 (DPP-4) serine aminopeptidase, which one the validated targets for Type 2 diabetes therapy due to its regulatory effect incretin hormone. Seven DPP-4 inhibitors are commercially available nowadays on market as drugs. They all chemically synthesized compounds with good therapeutic effects, but long-term safety remains unknown. On hand, nature provides rich source search desired safe effective medications; actually more than half drugs natural product related. Therefore, systematic new from sources seems be great utility developing novel antidiabetic This review summarized recent progress products, revealed that both pure products crude extracts herbs or hydrolyzates p...
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