Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria.
作者： Generoso M. Chagas , Annibal P. Campello , Ma. Lúcia W. Klüppel
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摘要: Citrinin depresses the phosphorylation efficiency of rat renal cortical mitochondria, as inferred from decrease respiratory control coefficient (RC) and ADP/O ratios. The transmembrane potential (delta psi) developed by energized mitochondria depolarization upon ADP addition are also decreased. (1.0 mM) inhibits almost all enzymes linked to chain increases activity succinate cytochrome c reductase oxidase (coupled). Malate glutamate dehydrogenases inhibited. inhibitory action citrinin on could be related following findings: effect complex I; ATP synthetase complex; partial inhibition potential.
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