Simultaneous exposure to nitric oxide inhibition and angiotensin II overload: is it a murine model of mitochondrial dysfunction in nonischemic heart failure?

摘要: Cardiac energy deprivation is the consequence of a complex alteration all bioenergetic cellular components dysfunctional myocardium. The study bioenergetics non-ischemic failing heart, challenging clinical entity with lack evidence for therapy, continues to be topic great interest. However, translation knowledge therapeutic purposes far from straightforward. development new pre-clinical models HF focused on regulation mitochondrial function should encouraged. Hamilton and coworkers developed reproducible murine model hypertensive associated induced by long-term treatment NG-nitro-L-arginine methyl ester (L-NAME, 0.3 mg/ml 1% NaCl, p.o.) angiotensin II (AngII, 0.7 mg/kg/day, s.c.). Despite limitations, this may improve our understanding mechanisms provide valuable tool test targeted strategies.