Impairment of Subendocardial Perfusion Reserve and Oxidative Metabolism in Nonischemic Dilated Cardiomyopathy

摘要: Abstract Background Cardiac magnetic resonance (CMR) and [ 11 C]acetate positron emission tomography (PET) were used to assess the hypothesis that patients with nonischemic dilated cardiomyopathy (NIDCM) have decreased subendocardial perfusion reserve impaired oxidative metabolism, consistent concept of “energy starvation” in heart failure (HF). Methods Results CMR myocardial was evaluated 13 NIDCM 15 control subjects coronary risk factors normal perfusion. The underwent PET. index (MPI) calculated as normalized rate signal augmentation following gadolinium contrast injection. Hyperemic transmural, subendocardial, subepicardial MPI reduced compared [0.13 vs 0.18 ( P  = .008), respectively]. 1.59 ± 0.21 1.86 ± 0.32 for subepicardium  = .002), demonstrating reserve. metabolic (k mono ) per unit demand (rate-pressure product) proportion  = .02) Conclusions Impaired confirmed results previously attained only animal models. metabolism are energy starvation HF.