OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN
作者： M Kazemi Arababadi , A Jafarzadeh , A Pourazar , M Mirzaei
DOI:
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摘要: Diagnosis of hepatitis B is routinely based on serological assay surface antigen (HBsAg). Occult virus (HBV) infection generally defined as the detection HBV -DNA in serum or tissues subjects who have negative test for HBsAg. Transmission has been documented from HBsAg negative, anti-HBc positive blood and organ donors. The aim this study was to determine rate occult among donors Rafsanjan transfusion center. Sera 270 healthy were both anti-HCV, tested antibodies by use ELISA technique. samples that but markers also examined presence HBV-DNA polymerase chain reaction (PCR). Out samples, 14 (5.18%) antibodies. detected 4/14 (28.57%) samples. Moreover, anti-HBs antibody 2/4 (50%) These results indicated found majority anti-HBc-positive In addition, present recommend incorporation routine screening a surrogate marker prevent some transfusion-transmitted infections.
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