Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep.
作者： Xuan Kang , Melanie Boly , Graham Findlay , Benjamin Jones , Klevest Gjini
DOI: 10.1038/S41598-020-58612-4
关键词:
摘要: In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration IEDs at scalp cortical levels using HD-EEG source-localization, during non-rapid eye movement (NREM) rapid (REM) sleep, six medication-refractory focal epilepsy patients monitoring unit admission. Statistical analyses were performed single subject level group stages for IEDs. Tests corrected multiple comparisons all channels time points. Compared NREM REM significantly shorter spatially more restricted. location also showed a higher concordance with electrographic ictal onset zone from recording. This study supports localizing value over suggests that may be clinical utility surgery work-up.
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