Neurodevelopmental models of schizophrenia: pathophysiologic synthesis and directions for intervention research.

摘要: This paper examines contemporary models of the pathophysiology schizophrenia from a neurodevelopmental perspective. Specifically, this article reviews recent research in neuropathology, neuroimaging, and developmental psychopathology schizophrenia, with an aim to critically evaluate several proposals concerning nature timing both neuroanatomic abnormalities underlying disorder their behavioral manifestations. Findings empirical literature are synthesized perspective dual cytoarchitectonic trends theory neurodevelopment, as well relation current conceptions prodrome. The evidence shows that sufficient groundwork has been laid begin longitudinal neuroimaging studies adolescents at clinical risk for determine more definitively disorder. Such information could have significant implications terms understanding prediction, treatment, and, ultimately, prevention schizophrenia.