Basal ganglia volumes in first-episode schizophrenia and healthy comparison subjects

摘要: Abstract Background: Previous studies suggest that dysfunction of cortico-striato-pallido-thalamic (CSPT) circuitry may be involved in the pathophysiology schizophrenia but also show basal ganglia structure is highly plastic and influenced by antipsychotic treatments. Controversy remains about whether pathology can detected vivo among treatment-naive patients. We conducted a magnetic resonance imaging (MRI) study to examine structures limbic forebrain first episode healthy comparison subjects. Methods: Fifty-one patients with first-episode 28 subjects participated study. A high-resolution, special contrast (white matter nulling) MRI sequence was used measure caudate nucleus, nucleus accumbens, putamen, subcommissural forebrain. Results: Volumes regions interest (adjusted for total brain volume age) did not differ significantly between groups. Age correlated putamen volumes bilaterally group, Conclusions: The findings there are no volumetric abnormalities before treatment schizophrenia. lack negative correlation age striatal implicate illness-associated factors alter normal age-related changes size.