Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain

摘要: Neuroblasts arising in the adult forebrain that travel to olfactory bulb use two modes of migration: tangentially, along rostral migratory stream, and radially, core where they start ascend outer layers. Although mechanisms tangential migration have been extensively studied, factors controlling radial remain unexplored. Here we report extracellular matrix glycoprotein tenascin-R, expressed mouse bulb, initiates both detachment neuroblasts from chains their migration. Expression tenascin-R is activity dependent, as it markedly reduced by odor deprivation. Furthermore, grafting tenascin-R-transfected cells into non-neurogenic regions reroutes migrating toward these regions. The identification an microenvironment capable directing provides insights regulating offers promising therapeutic venues for brain repair.