Invasive cervical cancer following cryotherapy for cervical intraepithelial neoplasia or human papillomavirus infection.

摘要: OBJECTIVE To determine the following: 1) causes for failure of cervical cryotherapy to prevent cancer, and 2) whether is associated with development adenocarcinoma rather than squamous carcinoma. METHODS We reviewed medical charts 327 women cancer. One hundred forty-seven whom pertinent history was missing were contacted by telephone or at clinic visits. History obtained verbally confirmed outside records. Cervical biopsies (N = 16) endocervical curettages (ECCs) 15) performed before diagnosis cancer 21) reviewed. RESULTS Twenty-one had a intraepithelial neoplasia (CIN) human papillomavirus infection (HPV). The interval between more 2 years in 19 5 ten. Several categories pre-treatment errors identified. Evaluation appropriate only nine cases. Interpretive noted three 16 ten 15 ECCs. After cryotherapy, 12% follow-up. Of invasive cancers that developed, 24% group 21% non-cryotherapy adenocarcinomas. CONCLUSIONS Careful evaluation accurate pathology reports, consistent long-term follow-up are necessary if be used treat CIN HPV. found no evidence adenocarcinoma.