Occult ovarian tumors in women with BRCA1 or BRCA2 mutations undergoing prophylactic oophorectomy.

摘要: PURPOSE: To review the findings at prophylactic oophorectomy of a series women who presented to familial breast and ovarian cancer clinic. MATERIALS AND METHODS: Data from medical charts, operative notes, pathology reports were collected on had undergone oophorectomies because elevated risk cancer. Because only subset patients underwent BRCA1 BRCA2 testing, each patient’s hereditary predisposition was calculated using Berry-Parmigiani model family history data. RESULTS: From June 1989 December 1998, 50 seen our clinic oophorectomy, 33 whom carrying germline or mutation greater than 25%. Among this group, four incidental tumors found (four 33, 12%); one tumor noted time surgery three in final pathology. Two microscopic, poorly differentiated serous adenocarcinomas multiple sites both ovarie...