Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer
作者： Qiushi Wang , Jingyuan Li , Guanghua Li , Yinghong Li , Chunlin Xu
DOI: 10.1007/S13277-013-1051-1
关键词:
摘要: Sphingosine kinase 2 (SphK2) as a conserved lipid has not been thoroughly elucidated in non-small cell lung cancer (NSCLC). The aim of the present study was to evaluate expression SphK2 NSCLC tissues and determine its correlation with clinicopathologic characteristics impact on patient prognosis. We assessed proliferating nuclear antigen (PCNA) (as proliferative index) by immunohistochemistry 180 patient's formalin-fixed paraffin-embedded tissue blocks. Relationship between PCNA various clinicopathological features these patients evaluated. detected that gradually upregulated from normal, metaplasia/dysplasia tissues. At same time, followed similar pattern. Statistical analysis showed strongly associated expression, histology grade, live vaccine strain invasion, lymph node status, clinical stage, tumors size, type. Patients overexpression their had lower overall survival (OS) disease-free (DFS) rates than those low expression. Using uni- multivariate analysis, we found an independent prognostic factor for both OS DFS. parallels progression NSCLC, may represent novel potentially biomarker prognosis NSCLC.
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