Treatment of urinary schistosomiasis with niridazole (Ambilhar) in 576 African schoolchildren.

摘要: Abstract In Dar es Salaam, 576 African school-children, age-distribution seven to sixteen years, began a course of niridazole ('Ambilhar', Ciba 32,644-Ba) treat their urinary schistosomiasis; 488 (84·7%) completed treatment. Of these 475 (97·3%) satisfactory monthly follow-up urine tests for four months. 25 mg. per kg. was given daily days. Half the children were treated with dose and other half split administered twice day. 13·5% complained minor symptoms but serious side-effects not encountered during After months' 92·6% on classed as " cured against 98·6% twice-daily dose. Failure occurred chiefly in boys (17 out total 22 failures both girls who or dose). The cure-rate (94·2%) lower than (98·5%). results showed significant difference higher those Because number failed complete treatment (21·0%) (9·7%), should be used outpatient mass-treatment children. A dose, somewhat cure-rate, inpatient also when it can reasonably ensured that child will take Since workers have neuropsychiatric some patients niridazole, particularly adults Schistosoma mansoni infections, caution use this drug is advocated until contraindications been further elucidated. Nevertheless, very valuable well-tolerated ambulatory schistosomiasis.