Treatment preferences and outcome in male hypogonadotropic hypogonadism: an Indian perspective.
作者： D. Sanyal , S. Chatterjee
DOI: 10.1111/AND.12480
关键词:
摘要: This retrospective study assessed treatment preferences and outcome with testosterone or HCG / HCG-FSH combination in Indian male idiopathic hypogonadotropic hypogonadism (IHH) subjects (n = 31) above 18 years of age. 38.7% IHH had no fertility plans chose 3 monthly intramuscular undecanoate. 73.7% human chorionic gonadotropin (HCG) alone due to cost considerations. Spermatogenesis occurred 21.4% on 60% follicle-stimulating hormone (FSH) combination. Treatment failure is higher than published Western rates. FSH regimen costly but superior alone. However, still persists, suggesting unknown testicular defect IHH.
sci-hub.se 参考文章(6)
Melvin M. Grumbach, A window of opportunity: the diagnosis of gonadotropin deficiency in the male infant. The Journal of Clinical Endocrinology and Metabolism. ,vol. 90, pp. 3122- 3127 ,(2005) , 10.1210/JC.2004-2465
Gerasimos P. Sykiotis, Xuan-Huong Hoang, Magdalena Avbelj, Frances J. Hayes, Apisadaporn Thambundit, Andrew Dwyer, Margaret Au, Lacey Plummer, William F. Crowley, Nelly Pitteloud, Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. The Journal of Clinical Endocrinology and Metabolism. ,vol. 95, pp. 3019- 3027 ,(2010) , 10.1210/JC.2009-2582
Peter Y. Liu, H. W. Gordon Baker, Veena Jayadev, Margaret Zacharin, Ann J. Conway, David J. Handelsman, Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. The Journal of Clinical Endocrinology and Metabolism. ,vol. 94, pp. 801- 808 ,(2009) , 10.1210/JC.2008-1648
Andrew A. Dwyer, Gerasimos P. Sykiotis, Frances J. Hayes, Paul A. Boepple, Hang Lee, Kevin R. Loughlin, Martin Dym, Patrick M. Sluss, William F. Crowley, Nelly Pitteloud, Trial of Recombinant Follicle-Stimulating Hormone Pretreatment for GnRH-Induced Fertility in Patients with Congenital Hypogonadotropic Hypogonadism The Journal of Clinical Endocrinology and Metabolism. ,vol. 98, ,(2013) , 10.1210/JC.2013-2518
S. BRYSON LEY, JOHN M. LEONARD, Male hypogonadotropic hypogonadism: factors influencing response to human chorionic gonadotropin and human menopausal gonadotropin, including prior exogenous androgens. The Journal of Clinical Endocrinology and Metabolism. ,vol. 61, pp. 746- 752 ,(1985) , 10.1210/JCEM-61-4-746
C. Wayne Bardin, Griff T. Ross, Arleen B. Rifkind, Charles M. Cargille, Mortimer B. Lipsett, Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients Journal of Clinical Investigation. ,vol. 48, pp. 2046- 2056 ,(1969) , 10.1172/JCI106170