Trial of Recombinant Follicle-Stimulating Hormone Pretreatment for GnRH-Induced Fertility in Patients with Congenital Hypogonadotropic Hypogonadism

摘要: Context and Objective: The optimal strategy for inducing fertility in men with congenital hypogonadotropic hypogonadism (CHH) is equivocal. Albeit a biologically plausible approach, pretreatment recombinant FSH (rFSH) before GnRH/human chorionic gonadotropin administration has not been sufficiently assessed. objective of the study was to test this method. Design Setting: This randomized, open-label treatment protocol at an academic medical center. Patients Interventions: GnRH-deficient prepubertal testes (<4 mL), no cryptorchidism, prior therapy were randomly assigned either 24 months pulsatile GnRH alone (inducing endogenous LH release) or 4 rFSH followed by therapy. underwent serial testicular biopsies, ultrasound assessments volume, serum hormone measurements, seminal fluid analyses. Results: increased inhibin B levels into normal range (...