Metabolic DNA and the problem of ageing.

作者: S.R. Pelc

DOI: 10.1016/0531-5565(70)90041-0

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摘要: Abstract The evidence for the existence and behaviour of metabolic DNA in higher organisms is reviewed. conclusions are that (a) a given type differentiated cell consists copies those genes which active cell, (b) working DNA, (c) while active, molecules subject to damage periodically renewed, probably through self-replication. It suggested faulty accumulate cells, leading diminished function. If it assumed full complement correct necessary peak performance smaller number average performance, shape curves describing decline function with age predicted. death ensues when all faulty, curve can be calculated accurately follows life tables mice Drosophila.

参考文章(31)
Maureen Owen, CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE · I Journal of Cell Biology. ,vol. 19, pp. 19- 32 ,(1963) , 10.1083/JCB.19.1.19
Georg Gerber, Gisela Gerber, Kurt I. Altman, The catabolism of tissue nucleic acid in the rat. I. The replacement time of deoxribonucleic acid. Journal of Biological Chemistry. ,vol. 235, pp. 1433- 1436 ,(1960) , 10.1016/S0021-9258(18)69425-6
Donald D. Brown, The genes for ribosomal RNA and their transcription during amphibian development. Current Topics in Developmental Biology. ,vol. 2, pp. 47- 73 ,(1967) , 10.1016/S0070-2153(08)60283-5
Van R. Potter, Liselotte I. Hecht, Nucleic acid metabolism in regenerating rat liver. I. The rate of deoxyribonucleic acid synthesis in vivo. Cancer Research. ,vol. 16, pp. 988- 993 ,(1956)
M. Sampson, D.D. Davies, Synthesis of a metabolically labile DNA in the maturing root cells of Vicia faba. Experimental Cell Research. ,vol. 43, pp. 669- 673 ,(1966) , 10.1016/0014-4827(66)90040-1
S.R. Pelc, Renewal of DNA in non-dividing cells and ageing Experimental Gerontology. ,vol. 1, pp. 215- 222 ,(1965) , 10.1016/0531-5565(65)90005-7
S. R. Pelc, L. F. La Cour, The incorporation of H3-thymidine in newly differentiated nuclei of roots of Vicia faba. Cellular and Molecular Life Sciences. ,vol. 15, pp. 131- 133 ,(1959) , 10.1007/BF02165521
G. J. NEARY, Ageing and radiation. Nature. ,vol. 187, pp. 10- 18 ,(1960) , 10.1038/187010A0